Structure of PDB 5ei9 Chain F Binding Site BS02

Receptor Information

>5ei9 Chain F (length=110) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KPYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRDKSHLLRHQ
RTHTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNKS
HLLRHQRTHT

Ligand information

>5ei9 Chain D (length=21) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tggcctccctagccacgtgga

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5ei9 Structural basis for human PRDM9 action at recombination hot spots.
Resolution	1.921 Å
Binding residue (original residue number in PDB)	S732 S760 H761 Y775 D786 K787 S788 K815 S816 L819 R823
Binding residue (residue number reindexed from 1)	S16 S44 H45 Y59 D70 K71 S72 K99 S100 L103 R107
Binding affinity	PDBbind-CN: Kd=36nM

Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.

External links

PDB	RCSB:5ei9, PDBe:5ei9, PDBj:5ei9
PDBsum	5ei9
PubMed	26833727
UniProt	Q9NQV7\|PRDM9_HUMAN Histone-lysine N-methyltransferase PRDM9 (Gene Name=PRDM9)

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