Structure of PDB 5eh2 Chain F Binding Site BS02

Receptor Information

>5eh2 Chain F (length=109) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRDKSHLLRHQR
THTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNKSH
LLRHQRTHT

Ligand information

>5eh2 Chain D (length=21) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tgaggcctccctagccacgtg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5eh2 Structural basis for human PRDM9 action at recombination hot spots.
Resolution	2.05 Å
Binding residue (original residue number in PDB)	S760 H761 Y775 D786 K787 S788 K815 S816 L819 R823
Binding residue (residue number reindexed from 1)	S43 H44 Y58 D69 K70 S71 K98 S99 L102 R106
Binding affinity	PDBbind-CN: Kd=28nM

Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.

External links

PDB	RCSB:5eh2, PDBe:5eh2, PDBj:5eh2
PDBsum	5eh2
PubMed	26833727
UniProt	Q9NQV7\|PRDM9_HUMAN Histone-lysine N-methyltransferase PRDM9 (Gene Name=PRDM9)

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