Structure of PDB 5a2q Chain F Binding Site BS02

Receptor Information
>5a2q Chain F (length=189) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQ
CPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNA
IINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRN
IKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR
Ligand information
>5a2q Chain 3 (length=257) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuccccugugaggaacuacugucuucacgcagaaagcgucuagccauggc
guuaguaugagugucgugcagccuccaggacccccccucccgggagagcc
auaguggucugcggaaccggugaguacaccggaauugcgagauuugggcg
ugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuug
ugguacugccugauagggugcuugcgagugccccgggaggucucguagac
caccaug
....<<<<.<<<<.....<<<<<..<<<.<<....<<<<<.......>>>
>>.....>>.>>>..>.>>>>>>>>>>>>......<<<<<<<<<<<.<<<
<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<<....>>>>.<<<<.
.>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....
>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.)))))....
.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5a2q Cryo-Em Structure of Hepatitis C Virus Ires Bound to the Human Ribosome at 3.9 Angstrom Resolution
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R130 G132 T133 V134 R135 N186 K191
Binding residue
(residue number reindexed from 1)		R115 G117 T118 V119 R120 N171 K176
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006450 regulation of translational fidelity
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5a2q, PDBe:5a2q, PDBj:5a2q
PDBsum5a2q
PubMed26155016
UniProtP46782|RS5_HUMAN Small ribosomal subunit protein uS7 (Gene Name=RPS5)

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