Structure of PDB 4ch8 Chain F Binding Site BS02

Receptor Information
>4ch8 Chain F (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSERNIEKISMLEKIYIHPRYNWRENLDRDIALMK
LKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGK
GQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGD
SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
DQF
Ligand information
Receptor-Ligand Complex Structure
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PDB4ch8 Gpibalpha Interacts Exclusively with Exosite II of Thrombin
Resolution1.75 Å
Binding residue
(original residue number in PDB)		R418 N504 F564 R565 K567 K568
Binding residue
(residue number reindexed from 1)		R94 N180 F240 R241 K243 K244
Enzymatic activity
Catalytic site (original residue number in PDB) H363 D419 E522 G523 D524 S525 G526
Catalytic site (residue number reindexed from 1) H43 D95 E198 G199 D200 S201 G202
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ch8, PDBe:4ch8, PDBj:4ch8
PDBsum4ch8
PubMed24316004
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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