Structure of PDB 2j4j Chain F Binding Site BS02

Receptor Information

>2j4j Chain F (length=226) Species: 273057 (Saccharolobus solfataricus P2)

MNIILKISGKFFDEDNVDNLIVLRQSIKELADNGFRVGIVTGGGSTARRY
IKLAREIGIGEAYLDLLGIWASRLNAYLVMFSLQDLAYMHVPQSLEEFIQ
DWSHGKVVVTGGFQPGQSTAAVAALVAEASSSKTLVVATNVDGVYEKDPR
IYADVKLIPHLTTQDLRKILEGSQSVQAGTYELLDPLAIKIVERSKIRVI
VMNYRKLNRIIDILKGEEVSSIIEPV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2j4j Chain F Residue 229

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2j4j Structural and Enzymatic Investigation of the Sulfolobus Solfataricus Uridylate Kinase Shows Competitive Utp Inhibition and the Lack of GTP Stimulation
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): R48 T180 Y181
• Binding residue (residue number reindexed from 1): R48 T180 Y181
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.4.22: UMP kinase.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0009041 UMP/dUMP kinase activity
• GO:0016301 kinase activity
• GO:0033862 UMP kinase activity

Biological Process

• GO:0006221 pyrimidine nucleotide biosynthetic process
• GO:0006225 UDP biosynthetic process
• GO:0016310 phosphorylation
• GO:0044210 'de novo' CTP biosynthetic process
• GO:0046940 nucleoside monophosphate phosphorylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2j4j, PDBe:2j4j, PDBj:2j4j
• PDBsum: 2j4j
• PubMed: 17297917
• UniProt: Q97ZE2|PYRH_SACS2 Uridylate kinase (Gene Name=pyrH)