Structure of PDB 1usy Chain F Binding Site BS02

Receptor Information

>1usy Chain F (length=202) Species: 243274 (Thermotoga maritima MSB8)

MLKLAIPKGRLEEKVMTYLKKTGVIFERESSILREGKDIVCFMVRPFDVP
TYLVHGVADIGFCGTDVLLEKETSLIQPFFIPTNISRMVLAGPKGRGIPE
GEKRIATKFPNVTQRYCESKGWHCRIIPLKGSVELAPIAGLSDLIVDITE
TGRTLKENNLEILDEIFVIRTHVVVNPVSYRTKREEVVSFLEKLQEVIEH
DS

Ligand information

• Ligand ID: HIS
• InChI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p+1/t5-/m0/s1
• InChIKey: HNDVDQJCIGZPNO-YFKPBYRVSA-O
• SMILES:
  OpenEye OEToolkits 1.5.0: c1c([nH+]c[nH]1)CC(C(=O)O)N
  CACTVS 3.341: N[CH](Cc1c[nH]c[nH+]1)C(O)=O
  CACTVS 3.341: N[C@@H](Cc1c[nH]c[nH+]1)C(O)=O
  ACDLabs 10.04: O=C(O)C(N)Cc1cnc[nH+]1
  OpenEye OEToolkits 1.5.0: c1c([nH+]c[nH]1)C[C@@H](C(=O)O)N
• Formula: C6 H10 N3 O2
• Name: HISTIDINE
• PDB chain: 1usy Chain F Residue 1204

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1usy Regulation of the Hetero-Octameric ATP Phosphoribosyl Transferase Complex from Thermotoga Maritima by a tRNA Synthetase-Like Subunit.
• Resolution: 2.52 Å
• Binding residue (original residue number in PDB): T65 Q77 R170 H172
• Binding residue (residue number reindexed from 1): T65 Q77 R170 H172
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.2.17: ATP phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0003879 ATP phosphoribosyltransferase activity
• GO:0005524 ATP binding
• GO:0016757 glycosyltransferase activity

Biological Process

• GO:0000105 L-histidine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1usy, PDBe:1usy, PDBj:1usy
• PDBsum: 1usy
• PubMed: 15660995
• UniProt: Q9X0D2|HIS1_THEMA ATP phosphoribosyltransferase (Gene Name=hisG)