Structure of PDB 1p8j Chain F Binding Site BS02

Receptor Information
>1p8j Chain F (length=468) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIE
KNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVAN
NGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPE
DDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDG
YTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLR
QKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLN
ADDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVE
PKDIGKRLEVRKAVTACLGEPNHITRLEHVQARLTLSYNRRGDLAIHLIS
PMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEA
NNYGTLTKFTLVLYGTAP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1p8j The Crystal Structure of the Proprotein Processing Proteinase Furin Explains its Stringent Specificity
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D154 D191 N192 H194 E236 S253 W254 G255 P256 E257 D258 D264 G294 N295 D306 Y308 S368
Binding residue
(residue number reindexed from 1)		D47 D84 N85 H87 E129 S146 W147 G148 P149 E150 D151 D157 G187 N188 D199 Y201 S261
Enzymatic activity
Catalytic site (original residue number in PDB) D153 H194
Catalytic site (residue number reindexed from 1) D46 H87
Enzyme Commision number 3.4.21.75: furin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1p8j, PDBe:1p8j, PDBj:1p8j
PDBsum1p8j
PubMed12794637
UniProtP23188|FURIN_MOUSE Furin (Gene Name=Furin)

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