Structure of PDB 8hfr Chain Ez Binding Site BS02

Receptor Information
>8hfr Chain Ez (length=290) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTPKYRLVVRF
TNKDIICQIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYATGLLI
ARRTLQKLGLDETYKGVEEVEGEYELTEAVEDGPRPFKVFLDIGLQRTTT
GARVFGALKGASDGGLYVPHSENRFPGWDFETEEIDPELLRSYIFGGHVS
QYMEELADDDEERFSELFKGYLADDIDADSLEDIYTSAHEAIRADPAFKP
TEKKFTKEQYAAESKKYRQTKLSKEERAARVAAKIAALAG
Ligand information
>8hfr Chain 2f (length=121) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacugu
aguuaagcugguaagagccugaccgaguaguguagugggugaccauacgc
gaaacucaggugcugcaaucu
<<<<<<<<<....<<<<<<<<.....<<.<<..............>>...
.>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>
.....>>>>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB8hfr Nuclear export of pre-60S particles through the nuclear pore complex.
Resolution2.64 Å
Binding residue
(original residue number in PDB)		S13 T18 F20 R21 R22 R24 T28 Y30 R33 R50 R54 T56 N57 K58 Q63 I69 D72 V74 G91 N94 Q151 T154 T155 R158 Y198 H203 Y207 E221 L222 P255 T256 F260 Y265 A266 E268 S269 Y272 T275 L277
Binding residue
(residue number reindexed from 1)		S8 T13 F15 R16 R17 R19 T23 Y25 R28 R45 R49 T51 N52 K53 Q58 I64 D67 V69 G86 N89 Q146 T149 T150 R153 Y193 H198 Y202 E216 L217 P250 T251 F255 Y260 A261 E263 S264 Y267 T270 L272
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8hfr, PDBe:8hfr, PDBj:8hfr
PDBsum8hfr
PubMed37258668
UniProtP26321|RL5_YEAST Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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