Structure of PDB 8hfr Chain EX Binding Site BS02

Receptor Information
>8hfr Chain EX (length=347) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDTISFLRGVLLKRYDPQTKLLNLGALHSDPELIQKGVQSKMFPAMMKLA
STEKSLIVESVNLADNQLKDISAISTLAQTFPNLKNLCLANNQIFRFRSL
EVWKNKFKDLRELLMTNNPITTDKLYRTEMLRLFPKLVVLDNVIVRDEQK
LQTVYSLPMKIQQFFFENDALGQSSTDFATNFLNLWDNNREQLLNLYSPQ
SQFSVSVDSTIPPSTVTDSDQTPAFGYYMSSSRNISKVSSEKSIQQRLSI
GQESINSIFKTLPKTKHHLQEQPNEYSMETISYPQINGFVITLHGFFEET
GKPELENNKLSKKSFDRTWVIVPMNNSVIIASDLLTVRAYSTGAWKT
Ligand information
>8hfr Chain 3n (length=156) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagc
gaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucu
uugaacgcacauugcgccccuugguauuccagggggcaugccuguuugag
cgucau
.........................................<<<<<<.<<
.....>>>.....(.<<<......>>..............>>>..)...>
>>....<<.....>><<<<<<<<<....>>>>>>>>>.............
......
Receptor-Ligand Complex Structure
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PDB8hfr Nuclear export of pre-60S particles through the nuclear pore complex.
Resolution2.64 Å
Binding residue
(original residue number in PDB)		S345 S346
Binding residue
(residue number reindexed from 1)		S239 S240
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0015288 porin activity
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0008033 tRNA processing
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0051028 mRNA transport
GO:0055085 transmembrane transport
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0042272 nuclear RNA export factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hfr, PDBe:8hfr, PDBj:8hfr
PDBsum8hfr
PubMed37258668
UniProtQ99257|MEX67_YEAST mRNA export factor MEX67 (Gene Name=MEX67)

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