Structure of PDB 7n2c Chain EF Binding Site BS02

Receptor Information

>7n2c Chain EF (length=685) Species: 83333 (Escherichia coli K-12)

SARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHGITITS
AATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCA
VGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGAN
PVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELA
NEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILVT
CGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDE
PFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQ
MHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPV
ISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELH
LDIIVDRMKREFNVEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQY
GHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGP
LAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEP
IMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFG
YATQLRSLTKGRASYTMEFLKYDEAPSNVAQAVIE

Ligand information

>7n2c Chain mR (length=12)

uguucaaagucu

............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7n2c Structural basis of early translocation events on the ribosome.
• Resolution: 2.72 Å
• Binding residue (original residue number in PDB): G511 R512
• Binding residue (residue number reindexed from 1): G496 R497

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0097216 guanosine tetraphosphate binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation
• GO:0032790 ribosome disassembly

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7n2c, PDBe:7n2c, PDBj:7n2c
• PDBsum: 7n2c
• PubMed: 34234344
• UniProt: P0A6M8|EFG_ECOLI Elongation factor G (Gene Name=fusA)