Structure of PDB 7z4o Chain EEE Binding Site BS02

Receptor Information
>7z4o Chain EEE (length=615) Species: 11320 (Influenza A virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEELNKRSYLIRALTLNTMTKDAER
GKLKRRAIATPGMQIRGFVYFVEALARSICEKLEQSGLPVGGNEKKAKLA
NVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWF
RNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQVPAEMLANIDLKYFNK
STREKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTK
TTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSY
INRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSVGVTVIKNN
MINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRAFELKKLWEQT
RSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPMNPFVS
HYDAVATTHSWIPKR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7z4o Chain EEE Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7z4o Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution3.412 Å
Binding residue
(original residue number in PDB)		G304 D305 D446 E491
Binding residue
(residue number reindexed from 1)		G271 D272 D413 E458
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z4o, PDBe:7z4o, PDBj:7z4o
PDBsum7z4o
PubMed35605026
UniProtA0A024E3M6

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