Structure of PDB 7aks Chain EEE Binding Site BS02

Receptor Information
>7aks Chain EEE (length=330) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSLSRFRGCLAGALLGDCVGSFYAAHDTVDLTSVLRHVQALYYTDDTAMA
RALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVVTVFKKLLNPKC
RDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQLTH
ASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDA
RELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIY
CFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIAGAYYGM
DQVPESWQQSCEGYEETDILAQSLHRVFQK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7aks Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal.
Resolution1.86 Å
Binding residue
(original residue number in PDB)		Y149 E275
Binding residue
(residue number reindexed from 1)		Y117 E243
Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
3.2.2.-
3.5.1.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0046872 metal ion binding
GO:0061463 O-acetyl-ADP-ribose deacetylase activity
GO:0140292 ADP-ribosylserine hydrolase activity
Biological Process
GO:0006281 DNA repair
GO:0006287 base-excision repair, gap-filling
GO:0060546 negative regulation of necroptotic process
GO:0071451 cellular response to superoxide
GO:0140290 peptidyl-serine ADP-deribosylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016604 nuclear body
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7aks, PDBe:7aks, PDBj:7aks
PDBsum7aks
PubMed34321462
UniProtQ9NX46|ADPRS_HUMAN ADP-ribosylhydrolase ARH3 (Gene Name=ADPRS)

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