Structure of PDB 6yxy Chain EA Binding Site BS02

Receptor Information
>6yxy Chain EA (length=532) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFNLPRERQILGGLHADWRTQMKRSGSILNDITPALPDTKRTEEQRRRVA
GWRPVVKLLGDQRLRIAIVGRMNSGKSSLFNLLRLEPTVPGRSNVVRDFD
GITRDSVEGQAQLEGMHFTIIDTPGMVQGRMVEEAFRTVETADAAIFVTA
VDEDIMPEELSLMQYLHLKHMPVVLLANKMDLIQEEEEEAVLDRYNSLGF
GNAIPFSARRKSGLEMLAAVLEPLYHIHAMHKVENDWDIEDLAMQGDESA
MEEIRERNCSDRFIRIAIVGRTNSGKSSLVNRLVGFERNRAVDEKNSTRD
PVELPCSYKGRKLKLIDTAGLARHRYRADRDFIGRIHGLSVNEIRFAHVV
IVVFDATEGHPNKYDMAVLHSVAAEGRPFLLCANKWDAVLDQSATAEAID
FKIKRQVREVKYSNAVVVSAHTGLNLTLLMDQALELYDKWNKRVRRAELT
RLWRKMEKSVIIPYHVARIGRITQVNTRPPTFLLQLQTKNDSNTLPKALQ
EMMKNTLVEEFDFRGVPIRLIQEVKDSNPDYI
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain6yxy Chain EA Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6yxy Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		N117 G119 K120 S121 S122 V140 R141 D142 G145 I146 T147 K223 D225 S251 A252 R253
Binding residue
(residue number reindexed from 1)		N73 G75 K76 S77 S78 V96 R97 D98 G101 I102 T103 K179 D181 S207 A208 R209
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6yxy, PDBe:6yxy, PDBj:6yxy
PDBsum6yxy
PubMed32679035
UniProtQ57TZ4

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