Structure of PDB 6hcm Chain E1 Binding Site BS02

Receptor Information
>6hcm Chain E1 (length=228) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIII
LATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIA
QAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSM
KFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPSGKIGP
KKPLPDHVSIVEPKDEILPTTPISEQKG
Ligand information
>6hcm Chain w3 (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB6hcm ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Resolution6.8 Å
Binding residue
(original residue number in PDB)		R117 R143 R146
Binding residue
(residue number reindexed from 1)		R117 R143 R146
Enzymatic activity
Enzyme Commision number 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0016829 lyase activity
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006412 translation
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0031334 positive regulation of protein-containing complex assembly
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051301 cell division
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005819 spindle
GO:0005840 ribosome
GO:0005856 cytoskeleton
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hcm, PDBe:6hcm, PDBj:6hcm
PDBsum6hcm
PubMed30293783
UniProtG1TNM3|RS3_RABIT Small ribosomal subunit protein uS3 (Gene Name=RPS3)

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