Structure of PDB 8wuv Chain E Binding Site BS02

Receptor Information

>8wuv Chain E (length=453) Species: 11801 (Moloney murine leukemia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLG
IKPHIQRLLDQGILVPCQSPWNTPLLPVKKPGTNDYRPVQDLREVNKRVE
DIHPTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQPLFAFEWR
DPEMGISGQLTWTRLPQGFKNSPTLFNEALHRDLADFRIQHPDLILLQYV
DDLLLAATSELDCQQGTRALLQTLGNLGYRASAKKAQICQKQVKYLGYLL
KEGQRWLTEARKETVMGQPTPKTPRQLREFLGKAGFCRLFIPGFAEMAAP
LYPLTKPGTLFNWGPDQQKAYQEIKQALLTAPALGLPDLTKPFELFVDEK
QGYAKGVLTQKLGPWRRPVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDA
GKLTMGQPLVILAPHAVEALVKQPPARMTHYQALLLDTDRVQFGPVVALN
PAT

Ligand information

>8wuv Chain F (length=34) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

caatccagactgagcacgctgtggtttggttgca

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8wuv Structural basis for pegRNA-guided reverse transcription by a prime editor.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	D225 R301 E302 G305
Binding residue (residue number reindexed from 1)	D202 R278 E279 G282

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:8wuv, PDBe:8wuv, PDBj:8wuv
PDBsum	8wuv
PubMed	38811740
UniProt	Q8UN00

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