Structure of PDB 8wut Chain E Binding Site BS02

Receptor Information

>8wut Chain E (length=453) Species: 11801 (Moloney murine leukemia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLG
IKPHIQRLLDQGILVPCQSPWNTPLLPVKKPGTNDYRPVQDLREVNKRVE
DIHPTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQPLFAFEWR
DPEMGISGQLTWTRLPQGFKNSPTLFNEALHRDLADFRIQHPDLILLQYV
DDLLLAATSELDCQQGTRALLQTLGNLGYRASAKKAQICQKQVKYLGYLL
KEGQRWLTEARKETVMGQPTPKTPRQLREFLGKAGFCRLFIPGFAEMAAP
LYPLTKPGTLFNWGPDQQKAYQEIKQALLTAPALGLPDLTKPFELFVDEK
QGYAKGVLTQKLGPWRRPVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDA
GKLTMGQPLVILAPHAVEALVKQPPARMTHYQALLLDTDRVQFGPVVALN
PAT

Ligand information

>8wut Chain F (length=22) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gagcaatccagactgagcacga

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8wut Structural basis for pegRNA-guided reverse transcription by a prime editor.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	Y222 R284 R298 R301 E302 G305 K306 F309 V402 R456
Binding residue (residue number reindexed from 1)	Y199 R261 R275 R278 E279 G282 K283 F286 V379 R427

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:8wut, PDBe:8wut, PDBj:8wut
PDBsum	8wut
PubMed	38811740
UniProt	Q8UN00

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