Structure of PDB 8wus Chain E Binding Site BS02

Receptor Information

>8wus Chain E (length=453) Species: 11801 (Moloney murine leukemia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLG
IKPHIQRLLDQGILVPCQSPWNTPLLPVKKPGTNDYRPVQDLREVNKRVE
DIHPTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQPLFAFEWR
DPEMGISGQLTWTRLPQGFKNSPTLFNEALHRDLADFRIQHPDLILLQYV
DDLLLAATSELDCQQGTRALLQTLGNLGYRASAKKAQICQKQVKYLGYLL
KEGQRWLTEARKETVMGQPTPKTPRQLREFLGKAGFCRLFIPGFAEMAAP
LYPLTKPGTLFNWGPDQQKAYQEIKQALLTAPALGLPDLTKPFELFVDEK
QGYAKGVLTQKLGPWRRPVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDA
GKLTMGQPLVILAPHAVEALVKQPPARMTHYQALLLDTDRVQFGPVVALN
PAT

Ligand information

>8wus Chain F (length=24) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

caatccagactgagcacgctgtga

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8wus Structural basis for pegRNA-guided reverse transcription by a prime editor.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	R110 F155 Q190 Y222 D224 R284 R298 R301 E302 G305 V402
Binding residue (residue number reindexed from 1)	R87 F132 Q167 Y199 D201 R261 R275 R278 E279 G282 V379

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:8wus, PDBe:8wus, PDBj:8wus
PDBsum	8wus
PubMed	38811740
UniProt	Q8UN00

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