Structure of PDB 8u8v Chain E Binding Site BS02

Receptor Information

>8u8v Chain E (length=990) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVML
GWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERC
LEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVN
TSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEK
PTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYP
FLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRV
SGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEALGAPEALREQPWPL
PVQMELGKLLAEMLVQATQMPCSLDKPHRSSRLVPVLYHVYSFRNVQQIG
ILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTK
LMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQ
LFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVA
REMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSD
VARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMD
DILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPV
HQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQ
DAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSD
FPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVE
WVTPLGVPVIQPYRLDSRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCY
RKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKR
FCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS

Ligand information

>8u8v Chain T (length=30) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ggtcgtctggcgtgcgcgccgttacaccat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8u8v Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Resolution	2.74 Å
Binding residue (original residue number in PDB)	Q493 R613 Q766 S774 R803 P811 H812 T996 G1000 T1002 Y1004 G1005 Q1009 Y1082
Binding residue (residue number reindexed from 1)	Q274 R394 Q547 S555 R584 P592 H593 T777 G781 T783 Y785 G786 Q790 Y863

External links

PDB	RCSB:8u8v, PDBe:8u8v, PDBj:8u8v
PDBsum	8u8v
PubMed	39164235
UniProt	O00411\|RPOM_HUMAN DNA-directed RNA polymerase, mitochondrial (Gene Name=POLRMT)

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