Structure of PDB 8u8u Chain E Binding Site BS02

Receptor Information

>8u8u Chain E (length=985) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAV
MLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIE
RCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPP
VNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSV
EKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSL
YPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQ
RVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEALGAPEALREQPW
PLPVQMELGKLLAEMLVQATQMPCSSRLVPVLYHVYSFRNVQQIGILKPH
PAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTV
EGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAK
GCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHS
LRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARAL
LEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDS
ADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGS
CNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRG
MRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEF
VWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPL
GVPVIQPYRLDSRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLT
FVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEP
QKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS

Ligand information

>8u8u Chain T (length=30) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ggtcgtctggcgtgcgcgccgttacaccat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8u8u Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	Q493 R613 R672 R759 L762 Q766 S774 E778 R803 P811 Y999 G1000 V1001 T1002 Y1004 G1005 Q1009 Y1082
Binding residue (residue number reindexed from 1)	Q276 R389 R448 R535 L538 Q542 S550 E554 R579 P587 Y775 G776 V777 T778 Y780 G781 Q785 Y858

External links

PDB	RCSB:8u8u, PDBe:8u8u, PDBj:8u8u
PDBsum	8u8u
PubMed	39164235
UniProt	O00411\|RPOM_HUMAN DNA-directed RNA polymerase, mitochondrial (Gene Name=POLRMT)

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