Structure of PDB 8u13 Chain E Binding Site BS02

Receptor Information

>8u13 Chain E (length=99) Species: 9606 (Homo sapiens)

KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQS
SAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Ligand information

>8u13 Chain J (length=146)

tcggatgtatatatctgacacgtgcctggagactagggagtaatcccctt
ggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgctag
agctgtctacgaccaattgagcggcctcggcaccgggattctcgat

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8u13 Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 1)
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): R42 T45 R49 R72 R83 F84 Q85 R116 V117 T118 M120
• Binding residue (residue number reindexed from 1): R6 T9 R13 R36 R47 F48 Q49 R80 V81 T82 M84

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0045296 cadherin binding

Biological Process

• GO:0006325 chromatin organization
• GO:0006334 nucleosome assembly
• GO:0010467 gene expression
• GO:0032200 telomere organization
• GO:0040029 epigenetic regulation of gene expression

Cellular Component

• GO:0000786 nucleosome
• GO:0005576 extracellular region
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0016020 membrane
• GO:0032991 protein-containing complex
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:8u13, PDBe:8u13, PDBj:8u13
• PDBsum: 8u13
• PubMed: 38242129
• UniProt: P68431|H31_HUMAN Histone H3.1 (Gene Name=H3C1)