Structure of PDB 8tw9 Chain E Binding Site BS02

Receptor Information

>8tw9 Chain E (length=1124) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AGNKYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKD
IDQIPGRVGWLTNMHATLVSGISGVDFYFLDEEGGSFKSTVVYDPYFFIA
CNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLS
FVNSNQLFEARKLLRPILQDNANNDAKHLIEDIREYDVPYHVRVSIDKDI
RVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIM
MISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALL
QRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAE
GEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELM
TPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLR
KGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVE
SLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTN
FEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSI
KAERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETF
PNKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVERE
AIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEA
KKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQ
MARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSM
LNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSK
EEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEG
DTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEY
EGQKSTSITTARRLGDFLDKGLQCKYIISSKPFNAPVTERAIPVAIFSAD
IPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQ
GVSNPVPRVEHPDWLKRKIATKED

Ligand information

>8tw9 Chain P (length=9) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tgttgctgc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8tw9 Cryo-EM reveals that Ctf18-RFC collaborates with PolE to load the PCNA clamp onto a leading strand DNA
Resolution	3.6 Å
Binding residue (original residue number in PDB)	Q434 R988 W1179
Binding residue (residue number reindexed from 1)	Q375 R929 W1114

External links

PDB	RCSB:8tw9, PDBe:8tw9, PDBj:8tw9
PDBsum	8tw9
PubMed
UniProt	P21951\|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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