Structure of PDB 8tkp Chain E Binding Site BS02

Receptor Information
>8tkp Chain E (length=187) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKGGVFTREQLDEYQDCTFFTRKDIIRLYKRFYALNPHKVPTNMQGNRPA
ITTLTFEEVEKMPELKENPFKRRICEVFSEDGRGNLSFDDFLDMFSVFSE
MAPLQLKLKYAFRIYDYDGDELLGHDDLSKMIRSLTRDELSDVEVEFIIE
RIIEEADLDGDSSINFAEFEHVVSRSPDFIRTFHIRI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8tkp Chain E Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8tkp The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D132 D134 L136 D141
Binding residue
(residue number reindexed from 1)		D118 D120 L122 D127
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0055074 calcium ion homeostasis

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Molecular Function
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Biological Process
External links
PDB RCSB:8tkp, PDBe:8tkp, PDBj:8tkp
PDBsum8tkp
PubMed38354260
UniProtQ93640

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