Structure of PDB 8th5 Chain E Binding Site BS02

Receptor Information
>8th5 Chain E (length=131) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKPSPLLVGREFVRQYYTLLNQAPDLHRFYGKNSSYVHGGLDKPADAVYG
QKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRR
FMQTFVLAPEGSVANKFYVHNDIFRYQDEVF
Ligand information
>8th5 Chain O (length=9) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ALRITFGGP
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8th5 Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		E14 F15 Q18 R32 F33 N122 K123 F124 Y125
Binding residue
(residue number reindexed from 1)		E11 F12 Q15 R28 F29 N115 K116 F117 Y118
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
External links
PDB RCSB:8th5, PDBe:8th5, PDBj:8th5
PDBsum8th5
PubMed38492217
UniProtQ13283|G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (Gene Name=G3BP1)

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