Structure of PDB 8poh Chain E Binding Site BS02

Receptor Information

>8poh Chain E (length=515) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))

EERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSK
EVNARIEPFLRTTPRPLRLPDGPPCSQRSKFLLMDALALSIEDPSHEGEG
IPLYDAIKCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIENE
EKIPRTKNMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPR
SLACWIQSEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVS
HCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKRRTKEGRRKTNLY
GFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLR
TAVGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESS
VKEKDLTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYA
SPQLEGFSAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVL
LNASWFNSFLTHALR

Ligand information

>8poh Chain U (length=14)

aguagaaacaaggg

.<<....>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8poh The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): K328 G371 N373 M374 A375 Y393 S395 E397 R508 H510 V517 R566 T567 N568 K574
• Binding residue (residue number reindexed from 1): K127 G170 N172 M173 A174 Y192 S194 E196 R307 H309 V316 R365 T366 N367 K373

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:8poh, PDBe:8poh, PDBj:8poh
• PDBsum: 8poh
• PubMed: 38316757
• UniProt: M9TI86