Structure of PDB 8ipr Chain E Binding Site BS02

Receptor Information

>8ipr Chain E (length=515) Species: 1772 (Mycolicibacterium smegmatis)

SYFQSNVVIAGCTIASAVVLAHIVAGIITNPATALGGETDWAPGLVALAV
LWSVRVVAQWFQGRLSQRGATAVIGELSRQVLSSVTTSSPRRLAADRDSA
AAVVTRGLDGLRPYFTGYLPAVVLAGILTPAALVVMAAYDWQAAAIVVIA
LPLIPIFMVLIGLLTAERSAAALTAMTTLQGRMLDLIAGIPTLRAVGRAG
GSVQRIAELSASHRRSTMATLRISFLSALVLELLATLGVALVAVSVGLRL
VFGDMTLAAGLTALLLAPEVFWPLRRVGAAFHAAQDGKTAAEQALRLCAE
PHPPTGHEVVPAGAPVIEVPALKAVMEPGRVTVLTGPNGVGKSTLLQAIL
GLQESPCGPILVAGVEVGALDRSAWWGRLAWMPHRPVLVPGTVRENLELL
GPVPGLDEVCRSVGFDEVLGELPDGSETPLGRGGVGLSLGQRQRLGLVRA
LGAPADVLLLDQPTAHLDGALEDRVLAAIVARARAGATVVMVGHRAPVLA
AADHVVTMESSLVAP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8ipr Chain E Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ipr Cryo-EM structures of a prokaryotic heme transporter CydDC.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): S337 H378
• Binding residue (residue number reindexed from 1): S343 H384
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.3.25: Transferred entry: 7.3.2.3.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0042883 cysteine transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8ipr, PDBe:8ipr, PDBj:8ipr
• PDBsum: 8ipr
• PubMed: 37144855
• UniProt: A0QXA6