Structure of PDB 8i7u Chain E Binding Site BS02

Receptor Information
>8i7u Chain E (length=391) Species: 1093098 (Streptomyces albogriseolus 1-36) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRHLSDGYWDSAARLGVHGAVLQAVPGGRLSAPDGRVAVNMSSYSYLGLD
ESPRIIDAAIAALRSNMVLNSSLGRVRMTLPLLEEAECALGDLFGADVAT
LNSCSAAAWATLPVLASGLLTDGVAPVMVFDKRAHFCMASLKSLCADETR
VETIRHNDVDALADICRKNKRVAYVCDSVYSTGGTLAPLEELFALQKEFG
LFLYFDEAHSTSVIGDMGRGYVLDRMGAINDSTMLITSLNKGFGASGGAI
VFGPRDDDRKRKIIQRSSGPLMWSQRLNTPALGAIIESAKLHRSEALPEL
QAKLHSNIALFDGLVRAAGQGNSVPIRYLELGSEVDTLEASAYLFDNGFY
VEPDFFPIVSRGAAGLRARIRSSMSTADIEQFAHVWHKLGV
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain8i7u Chain E Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8i7u Structural and mechanistic investigations on CC bond forming alpha-oxoamine synthase allowing L-glutamate as substrate.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		S116 C117 S118 H148 D219 A221 H222 S251 K254
Binding residue
(residue number reindexed from 1)		S103 C104 S105 H135 D206 A208 H209 S238 K241
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.47: 8-amino-7-oxononanoate synthase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8i7u, PDBe:8i7u, PDBj:8i7u
PDBsum8i7u
PubMed38642679
UniProtA0A6B9KSL0

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