Structure of PDB 8g5f Chain E Binding Site BS02

Receptor Information
>8g5f Chain E (length=331) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDY
TLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVH
GVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESY
GYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPR
LSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITT
VLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFF
GDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
Ligand information
Ligand IDABU
InChIInChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChIKeyBTCSSZJGUNDROE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370NCCCC(O)=O
ACDLabs 12.01O=C(O)CCCN
OpenEye OEToolkits 1.7.0C(CC(=O)O)CN
FormulaC4 H9 N O2
NameGAMMA-AMINO-BUTANOIC ACID;
GAMMA(AMINO)-BUTYRIC ACID
ChEMBLCHEMBL96
DrugBankDB02530
ZINCZINC000001532620
PDB chain8g5f Chain E Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8g5f Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Resolution2.64 Å
Binding residue
(original residue number in PDB)		Y97 E155 Y157 T202 Y205
Binding residue
(residue number reindexed from 1)		Y90 E148 Y150 T195 Y198
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g5f, PDBe:8g5f, PDBj:8g5f
PDBsum8g5f
PubMed37730991
UniProtP63137|GBRB2_MOUSE Gamma-aminobutyric acid receptor subunit beta-2 (Gene Name=Gabrb2)

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