Structure of PDB 8efr Chain E Binding Site BS02

Receptor Information
>8efr Chain E (length=766) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELR
KLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVV
GDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDS
SREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRM
VLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAE
RSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMK
ALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNL
SLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELF
EKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTM
NSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHD
DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAA
IYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNE
LEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRH
FLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTL
RQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVRE
IQEKLDAFIEALHQEK
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain8efr Chain E Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8efr OPA1 helical structures give perspective to mitochondrial dysfunction.
Resolution5.48 Å
Binding residue
(original residue number in PDB)		Q297 K301 M321
Binding residue
(residue number reindexed from 1)		Q103 K107 M127
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:8efr, PDBe:8efr, PDBj:8efr
PDBsum8efr
PubMed37612506
UniProtO60313|OPA1_HUMAN Dynamin-like GTPase OPA1, mitochondrial (Gene Name=OPA1)

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