Structure of PDB 8dh2 Chain E Binding Site BS02

Receptor Information
>8dh2 Chain E (length=841) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRK
MFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPTAF
QFLQEIKPEAVAYITIKTTLACLTTTVQAVASAIGRAIEDEARFGRIRDL
EAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAWSSWHKE
DSIHVGVRCIEMLIESTGMVSLHRQNASETIELAPEYAEAIATRAGALAG
ISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYM
PEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPAIAWKRAAAA
VYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFN
PQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIE
ENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLP
LAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQ
ADAINGTDNEVVTVTDENTGEISEKVKLGTKALAGQWLAYGVTRSVTKRS
VMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWE
SVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGF
PVWQEYKKPIQTRLNLMFLGQFRDSEIDAHKQESGIAPNFVHSQDGSHLR
KTVVWAHEKYGIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVL
ADFYDQFADQLHESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh2 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		N171 K172 K389 R394 R425 G436 I810 D812
Binding residue
(residue number reindexed from 1)		N164 K165 K356 R361 R392 G403 I768 D770
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh2, PDBe:8dh2, PDBj:8dh2
PDBsum8dh2
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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