Structure of PDB 8dh1 Chain E Binding Site BS02

Receptor Information
>8dh1 Chain E (length=785) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIPFNTLADHYGERLAREQLALEHESYEMGEARFRKMFERQLKAGEVADN
AAAKPLITTLLPKMIARINDIKPEAVAYITIKTTLACLTVASAIGRAIED
EARFGRIRDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLG
GEAWSSWHKEDSIHVGVRCIEMLIESTIELAPEYAEAIATRAGALAGISP
MFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEV
YKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPAIWKRAAAAVYRK
DKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGN
DMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHE
NIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFD
GSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAI
NGTDNEVVTVTDENTGEISEKVKLGTKALAGQWLAYGVTRSVTKRSVMTL
AYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSV
TVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQ
EYKKPIQTRLNLMFLGQDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWA
HEKYGIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQ
FADQLHESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh1 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		N171 K172 R386 K389 A390 R394 R425 G436 L752 H811 D812
Binding residue
(residue number reindexed from 1)		N124 K125 R299 K302 A303 R307 R338 G349 L665 H713 D714
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh1, PDBe:8dh1, PDBj:8dh1
PDBsum8dh1
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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