Structure of PDB 8cbk Chain E Binding Site BS02

Receptor Information
>8cbk Chain E (length=470) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSL
LAWVAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPR
GYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVN
TAWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNN
QLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQLS
PEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGL
NVAKMFPKVRESQLLLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEME
EVQKQASCFFADDISEDAPFLLYATLHSGNHCRFITRDLMRDHKACLPDA
KTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYD
EDLVERCSCEVPTKWLCLHQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8cbk Chain E Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8cbk Structural basis for human mitochondrial tRNA maturation.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		C348 H557
Binding residue
(residue number reindexed from 1)		C237 H446
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0004518 nuclease activity
GO:0004526 ribonuclease P activity
GO:0046872 metal ion binding
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0008033 tRNA processing
GO:0097745 mitochondrial tRNA 5'-end processing
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030678 mitochondrial ribonuclease P complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cbk, PDBe:8cbk, PDBj:8cbk
PDBsum8cbk
PubMed38824131
UniProtO15091|MRPP3_HUMAN Mitochondrial ribonuclease P catalytic subunit (Gene Name=PRORP)

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