Structure of PDB 7yq3 Chain E Binding Site BS02

Receptor Information

>7yq3 Chain E (length=830) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKD
DNEECGDICPCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC
HSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSF
CQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKP
WTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSS
SQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSCSC
PKTDSQILKELEESSFRKTFEDYLHNVVHRPFEKVVNKESLVISGLRHFT
GYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNV
VHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGL
SPGNYSVRIRATSLAGNGSWTEPTYFYVTD

Ligand information

>7yq3 Chain G (length=28) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tguauccgcaguaucggcauucagcgac

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7yq3 Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Resolution	3.6 Å
Binding residue (original residue number in PDB)	Y477 R479 L486 R488 Q546 W551
Binding residue (residue number reindexed from 1)	Y469 R471 L478 R480 Q538 W543

Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

External links

PDB	RCSB:7yq3, PDBe:7yq3, PDBj:7yq3
PDBsum	7yq3
PubMed	36310231
UniProt	P06213\|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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