Structure of PDB 7x4n Chain E Binding Site BS02

Receptor Information
>7x4n Chain E (length=332) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TCVQVALRIRPQGNREKLEGSRVCTSVLPNDPQVTIGGDRSFTYDHVFDM
PTLQYVVYESCVEKLVDGLFDGYNATVLAYGQTGSGKTHTMGTAFDAAVQ
KEEDLGVIPRAIQHTFRKIAECKAQAIEEPAFEVSVQFVELYNDDVLDLL
SDDRSIRIHEDSRGEIVLHGVEQRSVFDMHGTMDILKNGALNRTVAATNM
NEQSSRSHAIFTLHLKQQRVAEMLCAKFHFVDLAGSERMKRTGATGDRAK
EGISINVGLLALGNVIAALGGVSHVPYRDSKLTRLLQDSLGGNSRTLMIA
CCSPSDSDFVETLNTMKYANRAKEIKNKVVAN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7x4n Chain E Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7x4n Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 -tubulin complex.
Resolution2.88 Å
Binding residue
(original residue number in PDB)		T91 S217 D261
Binding residue
(residue number reindexed from 1)		T88 S205 D232
Annotation score4
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:7x4n, PDBe:7x4n, PDBj:7x4n
PDBsum7x4n
PubMed36065637
UniProtG5EGS3|KLP12_CAEEL Kinesin-like protein klp-12 (Gene Name=klp-12)

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