Structure of PDB 7wid Chain E Binding Site BS02

Receptor Information

>7wid Chain E (length=181) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IPTVIAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIY
LYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGK
RFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQS
IEKIQKDTDRDNFLTAEEAKEYGLIDEVMVP

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

7wid Chain E Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7wid Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	I81 P86
Binding residue (residue number reindexed from 1)	I70 P75
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.21.92: endopeptidase Clp.

Gene Ontology

	Molecular Function
GO:0004176	ATP-dependent peptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity
GO:0051117	ATPase binding

	Biological Process
GO:0006508	proteolysis
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins

	Cellular Component
GO:0005737	cytoplasm
GO:0009368	endopeptidase Clp complex

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Cellular Component

External links

PDB	RCSB:7wid, PDBe:7wid, PDBj:7wid
PDBsum	7wid
PubMed	36376309
UniProt	Q2G036\|CLPP_STAA8 ATP-dependent Clp protease proteolytic subunit (Gene Name=clpP)

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