Structure of PDB 7wi4 Chain E Binding Site BS02

Receptor Information
>7wi4 Chain E (length=410) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLTEDQIKTTFADVAGCDEAKEEVAELVEYLREPSRFQKLGGKIPKGVLM
VGPPGTGKTLLAKAIAGEAKVPFFTISGASRVRDMFEQAKKAAPCIIFID
QIREQTLNQMLVEMDGFEGNEGIIVIAATNRPGRFDRQVVVGLPDVRGRE
QILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAARGNKR
VVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHQAGHAIIGRLVPEH
DPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEI
IYGPEHVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAHMSDETARI
IDQEVKALIERNYNRARQLLTDNMDILHAMKDALMKYETIDAPQIDDLMA
RRDVRPPAGW
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7wi4 Chain E Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7wi4 Cryo-EM structure of the entire FtsH-HflKC AAA protease complex.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		H414 H418 D492
Binding residue
(residue number reindexed from 1)		H236 H240 D314
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030163 protein catabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0098796 membrane protein complex
GO:0098797 plasma membrane protein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wi4, PDBe:7wi4, PDBj:7wi4
PDBsum7wi4
PubMed35649372
UniProtP0AAI3|FTSH_ECOLI ATP-dependent zinc metalloprotease FtsH (Gene Name=ftsH)

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