Structure of PDB 7tjh Chain E Binding Site BS02

Receptor Information
>7tjh Chain E (length=439) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKY
FNANPNLHAVWLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPL
QVEEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDSLQDLDAALFNKYI
KLNELLPKDSKINIKFIYTMLETSFLQRYSTHCIPTVMFPRYNVDEVSTI
LVMSRCGELMEDSCLRKRIIEEDDQFQNVAANFIHLIVQAFHSYTGNDIF
ALNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLDLSIISK
YLLIASYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKKEVNPRYLQPS
LFAIERLLAIFQAIFPIALREESLMKANIEVFQNLSELHTLKLIATTMNK
NIDYLSPKVRWKVNVPWEIIKEISESVHFNISDYFSDIH
Ligand information
>7tjh Chain H (length=41) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tttgaaaagcaagcataaaagatctaaacataaaatctgta
Receptor-Ligand Complex Structure
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PDB7tjh A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y345 A362 Y363 G364 R365 R366 T436 K447
Binding residue
(residue number reindexed from 1)		Y316 A333 Y334 G335 R336 R337 T397 K408
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex
GO:0035361 Cul8-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tjh, PDBe:7tjh, PDBj:7tjh
PDBsum7tjh
PubMed35217664
UniProtP50874|ORC5_YEAST Origin recognition complex subunit 5 (Gene Name=ORC5)

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