Structure of PDB 7q3g Chain E Binding Site BS02

Receptor Information
>7q3g Chain E (length=517) Species: 1385624 (Desulfofustis sp. PB-SRB1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QNTGGNLDPAEEIDPAVSLGQVLEKALDLISELTAVADRIWDDDGGKGYS
ASLEFTIPRDSTITNQRLDKFQPTYTTGSFQSLEIKPEAHVQELEIRLDK
DTRYLTQHTRNLQPGDTFHALVRLRLTDSGGKPLAFGLIDQPGESVELNY
TCDQDICELVVHVDGTDGQKDSGEAVYRLLVGINAPNLRESGQTPVGSSV
FLESDLVTVGLAVDQIVGVDQRSENFSVVGTLKLSWHDPKLGFSPDQCGC
TVKSFEDASIRAVAGEINLPLPSFSFYNQQGNRWSQNQVIFVTPDGRASY
FERFTVTLQAPDFDFLAYPFDRQKFSIKVDLAVPTNMFIFNEIERFQQVV
GDQLGEEEWVVTSYSQEITEVPFERGSTNSRFTTTLLVKRNLEYYILRIF
VPLFLIISVSWVIFFLKDYGRQLEVASGNLLVFVAFNFTISGDLPRLGYL
TVLDRFMIVSFCLTAIVVLISVCQKRLGAVGKQAVAAQIDTWVLVIYPLV
YSLYIIWVYLRFFTDHI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7q3g Chain E Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7q3g Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		E347 P434
Binding residue
(residue number reindexed from 1)		E224 P311
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0007165 signal transduction
GO:0034220 monoatomic ion transmembrane transport
GO:0042391 regulation of membrane potential
Cellular Component
GO:0016020 membrane
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7q3g, PDBe:7q3g, PDBj:7q3g
PDBsum7q3g
PubMed36480474
UniProtV4JF97

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