Structure of PDB 7onu Chain E Binding Site BS02

Receptor Information
>7onu Chain E (length=467) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAW
VAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYS
LLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAW
NLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLY
PGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQLSPEE
YECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVA
KMFPKVRESQLLLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQ
KQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQ
RLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDEDL
VERCSCEVPTKWLCLHQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7onu Chain E Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7onu Structural basis of RNA processing by human mitochondrial RNase P.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D479 D499
Binding residue
(residue number reindexed from 1)		D365 D385
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0004518 nuclease activity
GO:0004526 ribonuclease P activity
GO:0046872 metal ion binding
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0008033 tRNA processing
GO:0097745 mitochondrial tRNA 5'-end processing
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030678 mitochondrial ribonuclease P complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7onu, PDBe:7onu, PDBj:7onu
PDBsum7onu
PubMed34489609
UniProtO15091|MRPP3_HUMAN Mitochondrial ribonuclease P catalytic subunit (Gene Name=PRORP)

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