Structure of PDB 7n27 Chain E Binding Site BS02

Receptor Information

>7n27 Chain E (length=56) Species: 9606 (Homo sapiens)

EELYEVERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIH
DFNRRH

Ligand information

>7n27 Chain K (length=5) Species: 32630 (synthetic construct)

cFAFK

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7n27 Crystal Structure of chromodomain of CDYL in complex with inhibitor UNC6261
• Resolution: 1.85 Å
• Binding residue (original residue number in PDB): E58 L60 Y61 E62 V63 W83 Y86 H98 L99 V100 C102 Y105
• Binding residue (residue number reindexed from 1): E1 L3 Y4 E5 V6 W26 Y29 H41 L42 V43 C45 Y48

Enzymatic activity

• Enzyme Commision number: 4.2.1.-

External links

• PDB: RCSB:7n27, PDBe:7n27, PDBj:7n27
• PDBsum: 7n27
• UniProt: Q9Y232|CDYL_HUMAN Chromodomain Y-like protein (Gene Name=CDYL)