Structure of PDB 7mqs Chain E Binding Site BS02

Receptor Information
>7mqs Chain E (length=806) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEE
CGDICPGTNCPATQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLH
HKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEK
TIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLK
IRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNL
TITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCE
NELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVVVDI
DPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSD
IIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWER
QAEDSELFELDYCLKGLKLPSRQILKELEESSFRKTFEDYLHNVVFVPRE
EHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSAR
TMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGD
EELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFY
VTDYLD
Ligand information
>7mqs Chain G (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCHSLQ
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mqs Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		D707 N711 V715 P716 R717
Binding residue
(residue number reindexed from 1)		D639 N643 V647 P648 R649
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:7mqs, PDBe:7mqs, PDBj:7mqs
PDBsum7mqs
PubMed35289328
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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