Structure of PDB 7mqo Chain E Binding Site BS02

Receptor Information
>7mqo Chain E (length=602) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEG
LCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVN
FSFCQDLHHKCKNSRCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVK
TLVTFSDERRTYGAKSDIIYVQTDQILKELEESSFRKTFEDYLHNVVFVP
RP
Ligand information
>7mqo Chain C (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCHSLQ
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mqo Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D496 D707 H710 N711 V713 F714 V715 P716 R717
Binding residue
(residue number reindexed from 1)		D488 D591 H594 N595 V597 F598 V599 P600 R601
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:7mqo, PDBe:7mqo, PDBj:7mqo
PDBsum7mqo
PubMed35289328
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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