Structure of PDB 7ka0 Chain E Binding Site BS02

Receptor Information
>7ka0 Chain E (length=835) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSNAMRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLGPV
DGPVTVGRVADIEELTGYKKPIRACAVDIGDRQYREIICGATNFAVGDLV
VVALPGATLPGGFTISARKAYGRNSDGMICSAAELNLGADHSGILVLPPG
AAEPGADGAGVLGLDDVVFHLAITPDRGYCMSVRGLARELACAYDLDFVD
PASNSRVPPLPIEGPAWPLTVQPETGVRRFALRPVIGIDPAAVSPWWLQR
RLLLCGIRATCPAVDVTNYVMLELGHPMHAHDRNRISGTLGVRFARSGET
AVTLDGIERKLDTADVLIVDDAATAAIGGVMGAASTEVRADSTDVLLEAA
IWDPAAVSRTQRRLHLPSEAARRYERTVDPAISVAALDRCARLLADIAGG
EVSPTLTDWRGDPPCDDWSPPPIRMGVDVPDRIAGVAYPQGTTARRLAQI
GAVVTHDGDTLTVTPPSWRPDLRQPADLVEEVLRLEGLEVIPSVLPPAPA
GRGLTAGQQRRRTIGRSLALSGYVEILPTPFLPAGVFDLWGLEADDSRRM
TTRVLNPLEADRPQLATTLLPALLEALVRNVSRGLVDVALFAIAQVVQPT
EQTRGVGLIPVDRRPTDDEIAMLDASLPRQPQHVAAVLAGLREPRGPWGP
GRPVEAADAFEAVRIIARASRVDVTLRPAQYLPWHPGRCAQVFVGESSVG
HAGQLHPAVIERSGLPKGTCAVELNLDAIPCSAPLPAPRVSPYPAVFQDV
SLVVAADIPAQAVADAVRAGAGDLLEDIALFDVFTGPQIGEHRKSLTFAL
RFRAPDRTLTEDDASAARDAAVQSAAERVGAVLRG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7ka0 Chain E Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ka0 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		S791 T793
Binding residue
(residue number reindexed from 1)		S795 T797
Annotation score1
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0009328 phenylalanine-tRNA ligase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ka0, PDBe:7ka0, PDBj:7ka0
PDBsum7ka0
PubMed33885823
UniProtP9WFU1|SYFB_MYCTU Phenylalanine--tRNA ligase beta subunit (Gene Name=pheT)

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