Structure of PDB 7k98 Chain E Binding Site BS02

Receptor Information
>7k98 Chain E (length=836) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQSNAMRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLGP
VDGPVTVGRVADIEELTGYKKPIRACAVDIGDRQYREIICGATNFAVGDL
VVVALPGATLPGGFTISARKAYGRNSDGMICSAAELNLGADHSGILVLPP
GAAEPGADGAGVLGLDDVVFHLAITPDRGYCMSVRGLARELACAYDLDFV
DPASNSRVPPLPIEGPAWPLTVQPETGVRRFALRPVIGIDPAAVSPWWLQ
RRLLLCGIRATCPAVDVTNYVMLELGHPMHAHDRNRISGTLGVRFARSGE
TAVTLDGIERKLDTADVLIVDDAATAAIGGVMGAASTEVRADSTDVLLEA
AIWDPAAVSRTQRRLHLPSEAARRYERTVDPAISVAALDRCARLLADIAG
GEVSPTLTDWRGDPPCDDWSPPPIRMGVDVPDRIAGVAYPQGTTARRLAQ
IGAVVTHDGDTLTVTPPSWRPDLRQPADLVEEVLRLEGLEVIPSVLPPAP
AGRGLTAGQQRRRTIGRSLALSGYVEILPTPFLPAGVFDLWGLEADDSRR
MTTRVLNPLEADRPQLATTLLPALLEALVRNVSRGLVDVALFAIAQVVQP
TEQTRGVGLIPVDRRPTDDEIAMLDASLPRQPQHVAAVLAGLREPRGPWG
PGRPVEAADAFEAVRIIARASRVDVTLRPAQYLPWHPGRCAQVFVGESSV
GHAGQLHPAVIERSGLPKGTCAVELNLDAIPCSAPLPAPRVSPYPAVFQD
VSLVVAADIPAQAVADAVRAGAGDLLEDIALFDVFTGPQIGEHRKSLTFA
LRFRAPDRTLTEDDASAARDAAVQSAAERVGAVLRG
Ligand information
>7k98 Chain F (length=77) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccagguagcucagucgguaugagcguccgccugaaaagcggaaggucg
gcgguucgaucccgccccuggccacca
<<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<
<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB7k98 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Resolution2.19 Å
Binding residue
(original residue number in PDB)		N-1 R358 H361 E555 A556 S578 R579
Binding residue
(residue number reindexed from 1)		N4 R363 H366 E560 A561 S583 R584
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0009328 phenylalanine-tRNA ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k98, PDBe:7k98, PDBj:7k98
PDBsum7k98
PubMed33885823
UniProtP9WFU1|SYFB_MYCTU Phenylalanine--tRNA ligase beta subunit (Gene Name=pheT)

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