Structure of PDB 7jpq Chain E Binding Site BS02

Receptor Information
>7jpq Chain E (length=404) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLE
LPHVFVNCVECFTLRLLLEQILNKLNHLSSTEITCETFNDFVRLFKQVTT
AENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIV
WEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINIL
LGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEASERDTRKLWRNIEPHL
KKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHVELPYYSKFILI
AAYLASYNPARTDKRFFLSNHLLGPKPFPLDRLLAILYSIVDSRVAPTAN
IFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIARTVNFDIIK
YLYD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7jpq Chain E Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7jpq The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		D125 K126
Binding residue
(residue number reindexed from 1)		D114 K115
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005694 chromosome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jpq, PDBe:7jpq, PDBj:7jpq
PDBsum7jpq
PubMed32808929
UniProtO43913|ORC5_HUMAN Origin recognition complex subunit 5 (Gene Name=ORC5)

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