Structure of PDB 7jl3 Chain E Binding Site BS02

Receptor Information
>7jl3 Chain E (length=650) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQG
QKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIV
ENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMF
NYLDQKLGGGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPKDEESRICKALFLY
TSHLRKYNDALIISEHARMKDALDYLKDFFSNVEIEQDLTQRFEEKLQEL
ESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWI
EGNPKLSFLKPGILTGRGGMTLPAQKCILDAFKGDHNILIATSVADEGID
IAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINM
YKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKENKKLLCRK
CKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKKRAKIFCARQN
CSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF
Ligand information
>7jl3 Chain Y (length=42) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucagucagucagucucagucagucagucucagucagucaguc
..........................................
Receptor-Ligand Complex Structure
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PDB7jl3 Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		I300 V514 K518 K635 R637 R664 T697 V699 K878 K880
Binding residue
(residue number reindexed from 1)		I62 V274 K278 K388 R390 R417 T442 V444 K610 K612
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7jl3, PDBe:7jl3, PDBj:7jl3
PDBsum7jl3
PubMed33373584
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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