Structure of PDB 7jk3 Chain E Binding Site BS02

Receptor Information
>7jk3 Chain E (length=398) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEAICSSLEPLFPCREAAIETLGELIGDSSETYPSAIYLFGHSGTGKTAL
TRAFLKECGKRQNVRTAHLNAIECYTTKIMLEILLDSLAPDQGDALKVDN
MLDFVEQLRRQAATRVEDQGFLIAVDNAERLRDMDANVLPVLLRLQELTN
LNLCVILLSQLPFEKFYNKTGLSEIVCLHLAQYNKAETQRILGSDFQQVR
NQLLEQKKRLEICQEAVTEDFYNNYLNLFLSVFYKACRDVPELQLTARKC
LSTYLEPVLDGSRLWRHIAGPLRSALTQIYMRIESLELPYYAKFLLIAAF
LASHNAAKQDKRLFVKLGPKSFSIDRLLAIFYAILEEKVGLTCNLLSQIS
TLVHLNLLSFVSGEQNIMEGSARLQCTIGLEFVLQIGKVVGFNVRQYL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7jk3 Chain E Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7jk3 Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		T48 D126
Binding residue
(residue number reindexed from 1)		T48 D126
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006270 DNA replication initiation
GO:0007052 mitotic spindle organization
GO:0007076 mitotic chromosome condensation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005664 nuclear origin of replication recognition complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7jk3, PDBe:7jk3, PDBj:7jk3
PDBsum7jk3
PubMed32848132
UniProtQ24169|ORC5_DROME Origin recognition complex subunit 5 (Gene Name=Orc5)

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