Structure of PDB 7ea8 Chain E Binding Site BS02

Receptor Information
>7ea8 Chain E (length=94) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQFKTDLRFQSAAI
GALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGE
Ligand information
>7ea8 Chain J (length=122) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tgcctggagactagggagtaatccccttggcggttaaaacgcgggggaca
gcgcgtacgtgcgtttaagcggtgctagagctgtctacgaccaattgagc
ggcctcggcaccgggattctcg
Receptor-Ligand Complex Structure
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PDB7ea8 Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R42 R63 R72 R83 F84 T118
Binding residue
(residue number reindexed from 1)		R4 R25 R34 R44 F45 T79
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
Cellular Component
GO:0000786 nucleosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:7ea8, PDBe:7ea8, PDBj:7ea8
PDBsum7ea8
PubMed33972509
UniProtQ6PI79|H33_XENLA Histone H3.3

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