Structure of PDB 7cx7 Chain E Binding Site BS02

Receptor Information

>7cx7 Chain E (length=495) Species: 235909,1202714

LSLRPYEFWFVTGSQHLYGEEALKQVEEHSRIMVNEWNRDSVFPFPFVFK
SVVTTPEEIRRVCLEANASEQCAGVVTWMHTFSPAKMWIGGLLELRKPLL
HLHTQFNRDIPWDSIDMDFMNLNQSAHGDREFGFMVTRLGMPRKVIVGHW
QDAEVARRVRGWAMTAVAAAVSRGLKVARFGDNMRQVAVTEGDKVEAEAR
FGWSVNGYGVGDLAERVRAVSEAEIDRLIDEYQSLYEFAPGCEKGGPLHD
GVREQARIELGLRSFLEEGGFEAFTTTFEDLHGMKQLPGLAVQRLMAEGY
GFGGEGDWKTAALVRLMKVMADGKGTSFMEDYTYHFEPGNEMILGAHMLE
VCPTIAATRPRIEVHPLSIGGKEDPARLVFDGGEGAAVNASLIDLGHRFR
LIVNEVDAVKPEHDMPKLPVARILWKPRPSLRDSAEAWILAGGAHHTCFS
FAVTTEQLQDFAEMAGIECVVINEHTSVSSFKNELKWNEVFWRGR

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 7cx7 Chain E Residue 504

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7cx7 Crystal structure of Arabinose isomerase from hyper thermophilic bacterium Thermotoga maritima (TMAI) wt
• Resolution: 2.49 Å
• Binding residue (original residue number in PDB): E307 E332 H349 H447 H448
• Binding residue (residue number reindexed from 1): E305 E330 H347 H445 H446
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.4: L-arabinose isomerase.

Gene Ontology

Molecular Function

• GO:0008733 L-arabinose isomerase activity
• GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses

Biological Process

• GO:0005996 monosaccharide metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7cx7, PDBe:7cx7, PDBj:7cx7
• PDBsum: 7cx7
• UniProt: K0IGW6;
  Q5KYP7|ARAA_GEOKA L-arabinose isomerase (Gene Name=araA)