Structure of PDB 6zbn Chain E Binding Site BS02
Receptor Information
>6zbn Chain E (length=198) Species:
9606
(Homo sapiens) [
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PALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGDKITW
IEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGT
GYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEP
KFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTG
Ligand information
Ligand ID
MN
InChI
InChI=1S/Mn/q+2
InChIKey
WAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341
[Mn++]
Formula
Mn
Name
MANGANESE (II) ION
ChEMBL
DrugBank
DB06757
ZINC
PDB chain
6zbn Chain E Residue 502 [
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Receptor-Ligand Complex Structure
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PDB
6zbn
Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat.
Resolution
2.01 Å
Binding residue
(original residue number in PDB)
H313 D315 H374
Binding residue
(residue number reindexed from 1)
H105 D107 H166
Annotation score
1
Enzymatic activity
Enzyme Commision number
1.14.11.29
: hypoxia-inducible factor-proline dioxygenase.
Gene Ontology
Molecular Function
GO:0005506
iron ion binding
GO:0016705
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418
L-ascorbic acid binding
View graph for
Molecular Function
External links
PDB
RCSB:6zbn
,
PDBe:6zbn
,
PDBj:6zbn
PDBsum
6zbn
PubMed
33792169
UniProt
Q9GZT9
|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)
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