Structure of PDB 6qwl Chain E Binding Site BS02

Receptor Information

>6qwl Chain E (length=511) Species: 408929 (Influenza B virus (B/Panama/45/1990))

QTISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSATPK
KLKWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTL
AKECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNE
LQKTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQT
EMNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVM
MKYVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQS
HLRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYL
YCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFK
GDRVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFS
AESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNE
WLGFEKEGSKV

Ligand information

>6qwl Chain W (length=14)

agcaaaagcaggcc

.<<....>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qwl Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): G367 G369 L370 T371 K374 E389 E390 K392 Q504 H506 V513 K535 N560 A649
• Binding residue (residue number reindexed from 1): G162 G164 L165 T166 K169 E184 E185 K187 Q299 H301 V308 K330 N355 A444

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6qwl, PDBe:6qwl, PDBj:6qwl
• PDBsum: 6qwl
• PubMed: 31485076
• UniProt: O36432|PA_INBP9 Polymerase acidic protein (Gene Name=PA)